1h-Isoindol-1-one,2,3-dihydro-5-(4-nitrophenoxy)- → 1h-Isoindol-1-one,5-(4-aminophenoxy)-2,3-dihydro-

HRID 78315노트

반응식

HRID 78315 반응식
[C:1]1(=[O:20])[C:9]2[C:4](=[CH:5][C:6]([O:10][C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=3)=[CH:7][CH:8]=2)[CH2:3][NH:2]1>CCO.[Pd]>[O:20]=[C:1]1[C:9]2[C:4](=[CH:5][C:6]([O:10][C:11]3[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=3)=[CH:7][CH:8]=2)[CH2:3][NH:2]1

참가 물질

4

반응물 1

HCID 231372471h-Isoindol-1-one,2,3-dihydro-5-(4-nitrophenoxy)-

생성물 1

HCID 231372161h-Isoindol-1-one,5-(4-aminophenoxy)-2,3-dihydro-

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A slurry of 4-(1-isoindolinon-5-yloxy)-1-nitrobenzene (2.12 g, 7.8 mmol) and 10% Pd/C (0.20 g) in EtOH (50 mL) was stirred under an H2 atmosphere (balloon) for 4 h, then filtered through a pad of Celite®. The filtrate was concentrated under reduced pressure to afford 4-(1-oxoisoindolin-5-yloxy)aniline as a dark yellow solid: TLC (100% EtOAc) Rf 0.15.

후처리

  1. filtrationfiltered through a pad of Celite®
  2. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a07a612fb477410a8caa0005ccd6d758
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841330B2

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