Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-methyl-3-(4-nitrophenoxy)benzamide → 3-(4-Aminophenoxy)-N-methylbenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-methyl-3-(4-nitrophenoxy)benzamide | HCID 23614569 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 3-(4-Aminophenoxy)-N-methylbenzamide | HCID 23614570 | 56.4% |
반응 단계
A slurry of 4-(3-(N-methylcarbamoyl)phenoxy)-1-nitrobenzene (1.89 g, 6.95 mmol) and 5% Pd/C (0.24 g) in EtOAc (20 mL) was stirred under an H2 atm (balloon) overnight. The resulting mixture was filtered through a pad of Celite® and concentrated under reduced pressure. The residue was purified by column chromatography (5% MeOH/95% CH2Cl2). The resulting oil solidified under vacuum overnight to give 4-(3-(N-methylcarbamoyl)phenoxy)aniline as a yellow solid (0.95 g, 56%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841330B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-da55d700fac14d36b471bae4b46d4609 |
| 출처 메모 | uspto-grants-2014_09 |