Oxalyl chloride → 2,2,3,3-Tetramethylcyclopropane-1-carbonyl chloride
반응식
[CH3:1][C:2]1([CH3:10])[C:4]([CH3:6])([CH3:5])[CH:3]1[C:7](O)=[O:8].C(Cl)(=O)C([Cl:14])=O>C(Cl)Cl.CN(C)C=O>[CH3:1][C:2]1([CH3:10])[C:4]([CH3:6])([CH3:5])[CH:3]1[C:7]([Cl:14])=[O:8]참가 물질
5
실험 절차
To a solution of 2,2,3,3-tetramethylcyclopropanecarboxylic acid (0.50 g, 3.5 mmol) in 18 mL of methylene chloride at 0° C. was added oxalyl chloride (0.61 mL, 7.0 mmol) and a catalytic amount of dimethylformamide (2 drops). The solution was stirred at ambient temperature for 1 hour, and then concentrated under reduced pressure to provide 0.56 g of the title compound.
후처리
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-023c8dfe939e46a6aa48663fb87cc7c3
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08841334B2
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