Thionyl Chloride → 5-Fluoro-2-methylbenzoyl chloride

HRID 78404

반응식

HRID 78404 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7](O)=[O:8].S(Cl)([Cl:14])=O>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7]([Cl:14])=[O:8]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 1821145-Fluoro-2-methylbenzoic acid

생성물 1

HCID 27373835-Fluoro-2-methylbenzoyl chloride

실험 절차

A solution of 5-fluoro-2-methylbenzoic acid (380 mg, 2.47 mmol) in thionyl chloride (5 mL) was heated to reflux for 3 hours. The solution was cooled to ambient temperature and the volatile components were removed under reduced pressure. The residue was dissolved in fresh toluene (10 mL) and concentrated under reduced pressure twice and then placed under high vacuum to afford the title compound (420 mg).

후처리

  1. temperatureto reflux for 3 hours
  2. customthe volatile components were removed under reduced pressure
  3. dissolutionThe residue was dissolved in fresh toluene (10 mL)
  4. concentrationconcentrated under reduced pressure twice

출처 및 근거

ORD 기록
ord-fdb9a3548b704bb7936d45fb4cc7b307
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841334B2

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