5-Chloro-o-anisic acid → HCID 178495826, 화합물

HRID 78416

반응식

HRID 78416 반응식
Br.[F:2][C:3]1[CH:16]=[CH:15][C:6]2[N:7]([CH2:11][CH2:12][O:13][CH3:14])[C:8](=[NH:10])[S:9][C:5]=2[CH:4]=1.[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([O:27][CH3:28])=[C:22]([CH:26]=1)[C:23](O)=[O:24]>>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([O:27][CH3:28])=[C:22]([CH:26]=1)[C:23](/[N:10]=[C:8]1\[S:9][C:5]2[CH:4]=[C:3]([F:2])[CH:16]=[CH:15][C:6]=2[N:7]\1[CH2:11][CH2:12][O:13][CH3:14])=[O:24]

참가 물질

3

반응물 2

HCID 769705-Chloro-o-anisic acidHCID 686235486-Fluoro-3-(2-methoxyethyl)-3H-benzothiazol-2-ylideneamine hydrobromide

생성물 1

HCID 178495826HCID 178495826, 화합물

실험 절차

The product from Example 113A and 5-chloro-2-methoxybenzoic acid were processed using the methods described in Example 13 to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 3.24 (s, 3H), 3.79 (t, J=5.3 Hz, 2H), 3.83 (s, 3H), 4.65 (t, J=5.3 Hz, 2H), 7.17 (d, J=9.2 Hz, 1H), 7.41 (td, J=9.1, 2.5 Hz, 1H), 7.52 (dd, J=8.8, 2.7 Hz, 1H), 7.78 (dd, J=9.0, 4.2 Hz, 1H), 7.83 (d, J=2.7 Hz, 1H), 7.89 (dd, J=8.5, 2.7 Hz, 1H); MS (ESI+) m/z 395 (M+H)+; Anal. Calculated for C18H16ClFN2O3S: C, 54.75; H, 4.08; N, 7.09. Found: C, 54.29; H, 3.94; N, 6.99.

출처 및 근거

ORD 기록
ord-bd2a63315b4e469b9fa4205b949d221c
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841334B2

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