2,4-Dimethoxybenzoic acid → 2,4-Dimethoxybenzoyl chloride

HRID 78466

반응식

HRID 78466 반응식
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:4]=1[C:5](O)=[O:6].O=S(Cl)[Cl:16]>>[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:4]=1[C:5]([Cl:16])=[O:6]

참가 물질

3

반응물 2

HCID 70522,4-Dimethoxybenzoic acidHCID 24386Thionyl Chloride

생성물 1

HCID 27347192,4-Dimethoxybenzoyl chloride

실험 절차

A solution of 2,4-dimethoxybenzoic acid (0.25 g, 1.4 mmol) in 5 mL of SOCl2 was warmed to reflux and was allowed to stir for 2 hours. The mixture was cooled to ambient temperature and concentrated under reduced pressure. The crude material was diluted with 5 mL of toluene and concentrated under reduced pressure. This dilution with toluene and concentration was repeated two additional times to give the crude title compound which was used without additional purification or characterization.

후처리

  1. temperatureto reflux
  2. concentrationconcentrated under reduced pressure
  3. additionThe crude material was diluted with 5 mL of toluene
  4. concentrationconcentrated under reduced pressure
  5. concentrationThis dilution with toluene and concentration

출처 및 근거

ORD 기록
ord-bd29039174134ba49dfadb7c87cf493a
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841334B2

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