Allyl bromide → 3-allyl-4,5-dimethylthiazol-2(3H)-imine hydrobromide

HRID 78488

반응식

HRID 78488 반응식
[CH3:1][C:2]1[N:3]=[C:4]([NH2:8])[S:5][C:6]=1[CH3:7].[CH2:9]([Br:12])[CH:10]=[CH2:11]>C1(C)C=CC=CC=1.CCOCC>[BrH:12].[CH2:11]([N:3]1[C:2]([CH3:1])=[C:6]([CH3:7])[S:5][C:4]1=[NH:8])[CH:10]=[CH2:9]

참가 물질

5

반응물 2

HCID 7841Allyl bromideHCID 732382-Amino-4,5-dimethyl-1,3-thiazole

생성물 1

HCID 686235423-allyl-4,5-dimethylthiazol-2(3H)-imine hydrobromide

시약·촉매·용매 2

HCID 1140Toluene용매HCID 3283Diethyl Ether용매

반응 조건

온도
85 °C

실험 절차

A mixture of 4,5-dimethyl-1,3-thiazol-2-amine (1 g) and allylbromide (0.95 g) in toluene (5 mL) was heated to 85° C. for 12 hours, cooled, diluted with ether, filtered and the solvent was evaporated to afford crude product that was taken on to the next step without further characterization.

후처리

  1. temperaturecooled
  2. filtrationfiltered
  3. customthe solvent was evaporated
  4. customto afford crude product that

출처 및 근거

ORD 기록
ord-b550bf94e1dc44afbb8ef0c33f28bdba
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841334B2

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