참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Propargyl bromide | HCID 7842 | — |
| 반응물 | 2-Amino-4,5-dimethyl-1,3-thiazole | HCID 73238 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 4,5-dimethyl-3-(prop-2-ynyl)thiazol-2(3H)-imine hydrobromide | HCID 86640857 | 72.6% |
반응 단계
To a solution of 4,5-dimethylthiazol-2-amine (2.5 g, 19.5 mmol) in 10 mL toluene was added propargyl bromide (2.78 g, 23.4 mmol). The reaction was heated at 85° C. for 12 h then cooled. The crude material was diluted with diethyl ether and the solid was collected via filtration to give 3.5 g of the title compound which was used without further purification. m/z 167.1 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08841334B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-b6f5b5843ebb4d588a2e5b6422eff13e |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
