Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-Acetylserotonin → 3-[2-(acetylamino)ethyl]-1H-indol-5-yl 4-nitrophenyl carbonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-Acetylserotonin | HCID 903 | — |
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-[2-(acetylamino)ethyl]-1H-indol-5-yl 4-nitrophenyl carbonate | HCID 86712985 | 60% |
반응 단계
To N-acetylserotonin (0.9 g; 4 mmol) was added N-methylmorpholine (0.92 ml, 8 mmol), and 4-nitrophenyl chloroformate (1.61 g; 8 mmol) dissolved in tetrahydrofuran. Reaction was carried out for 0.5 h under an argon atmosphere. The solvent was evaporated. The residue was purified by column chromatography (SiO2, methanol/methylene chloride) to give 0.92 g (yield 60%) of crystalline yellow product with a melting point 153-156° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841453B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-cb0d748909484c0fa6ac05719d52db41 |
| 출처 메모 | uspto-grants-2014_09 |