Sodium Sulfite → Ethyl-2-(2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate
반응식
[CH2:1]([O:3][C:4](=[O:16])[C:5]([C:7]1(Br)[CH2:11][CH2:10][O:9][CH:8]1[O:12][CH2:13][CH3:14])=[O:6])[CH3:2].S([O-])([O-])=O.[Na+].[Na+]>ClCCl>[CH2:1]([O:3][C:4](=[O:16])[C:5]([CH:7]1[CH2:11][CH2:10][O:9][CH:8]1[O:12][CH2:13][CH3:14])=[O:6])[CH3:2]참가 물질
4
실험 절차
Ethyl-2-(3-bromo-2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate (100 g) dissolved in dichloromethane (500 ml). Sodium sulphite solution (15%, 1000 ml) was added to it. Reaction mass was stirred for 8 hrs. Organic and aqueous layer separated dichloromethane layer was washed with water (2×200 ml). Dichloromethane layer was then concentrated to residue to get Ethyl-2-(2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate (Yield 67 g)
후처리
- customReaction mass
- customOrganic and aqueous layer separated dichloromethane layer
- washwas washed with water (2×200 ml)
- concentrationDichloromethane layer was then concentrated to residue
출처 및 근거
- ORD 기록
- ord-1c0b3c08f3254dceba8884123e9da8d8
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08841467B2
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