Ethanol → Ethyl-2-(2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate
반응식
[CH2:1]([O:3][C:4](=[O:12])[C:5]([C:7]1[CH2:11][CH2:10][O:9][CH:8]=1)=[O:6])[CH3:2].[CH2:13]([OH:15])[CH3:14]>ClCCl>[CH2:1]([O:3][C:4](=[O:12])[C:5]([CH:7]1[CH2:11][CH2:10][O:9][CH:8]1[O:15][CH2:13][CH3:14])=[O:6])[CH3:2]참가 물질
4
반응 조건
- 온도
- 45 °C
실험 절차
Ethyl-2-(4,5-dihydrofuran-3-yl)-2-oxoacetate (10 g) was dissolved in Ethanol (50 ml) and Dichloromethane (50 ml). The reaction mass was stirred at 40-50° C. for 12 hrs. Reaction mass was concentrated to residue under vacuum at 40° C. Residue was dissolved in dichloromethane (50 ml) and washed with water (50 ml). Reaction mass was concentrated to residue to get ethyl-2-(2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate (Yield 9.9 g).
후처리
- customReaction mass
- concentrationwas concentrated to residue under vacuum at 40° C
- dissolutionResidue was dissolved in dichloromethane (50 ml)
- washwashed with water (50 ml)
- customReaction mass
- concentrationwas concentrated to residue
출처 및 근거
- ORD 기록
- ord-6141a388ef844357989524e640371ea6
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08841467B2
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