Methane → Ethyl-2-(2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate

반응식

[CH2:1]([O:3][C:4](=[O:12])[C:5]([C:7]1[CH2:11][CH2:10][O:9][CH:8]=1)=[O:6])[CH3:2].C.[CH2:14]([OH:16])[CH3:15]>>[CH2:1]([O:3][C:4](=[O:12])[C:5]([CH:7]1[CH2:11][CH2:10][O:9][CH:8]1[O:16][CH2:14][CH3:15])=[O:6])[CH3:2]

참가 물질

반응물 3

HCID 297Methane

HCID 702Ethanol

HCID 11571862HCID 11571862, 화합물

생성물 1

HCID 67607633Ethyl-2-(2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate

반응 조건

온도: 45 °C

실험 절차

Ethyl-2-(4,5-dihydrofuran-3-yl)-2-oxoacetate (10 g) was dissolved in Ethanol (50 ml) and Methane sulphoic acid (0.1 ml) was added to it. The reaction mass was stirred at 40-50° C. for 12 hrs. Reaction mass was concentrated to residue under vacuum. Residue was dissolved in dichloromethane (50 ml) and washed with water (50 ml). Reaction mass was concentrated to residue to get ethyl-2-(2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate (Yield 9.2 g).