Methylamine → 3-[(2-chloro-4-iodophenyl)amino]-N-methylisonicotinamide

반응식

[Cl:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[CH3:19][NH2:20]>>[Cl:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([NH:20][CH3:19])=[O:14]

참가 물질

반응물 2

HCID 6329Methylamine

HCID 576496513-[(2-Chloro-4-iodophenyl)amino]isonicotinic acid2회

생성물 1

HCID 116681963-[(2-chloro-4-iodophenyl)amino]-N-methylisonicotinamide

실험 절차

3-[(2-chloro-4-iodophenyl)amino]-N-methylisonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.32 mmol of 3-[(2-chloro-4-iodophenyl)amino]isonicotinic acid (intermediate 2) and 0.43 mmol of monomethylamine LC/MS [9.23 min; 389 (M+1)]

출처 및 근거

ORD 기록: ord-38503d46ac664280ac0f152ab9434014
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08841459B2

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