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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 78840생성일: 2026년 10월 25일

O-(Tetrahydropyran-2-yl)hydroxylamine → 3-[(2-fluoro-4-iodophenyl)amino]-N-(tetrahydro-2H-pyran-2-yloxy)isonicotin-amide

https://huagongshe.com/reaction/78840

반응식

참여 물질

역할이름HCID투입량
반응물O-(Tetrahydropyran-2-yl)hydroxylamineHCID 5142091—
반응물3-((2-Fluoro-4-iodophenyl)amino)isonicotinic acidHCID 59026791—
생성물3-[(2-fluoro-4-iodophenyl)amino]-N-(tetrahydro-2H-pyran-2-yloxy)isonicotin-amideHCID 11691076—

반응 단계

3-[(2-fluoro-4-iodophenyl)amino]-N-(tetrahydro-2H-pyran-2-yloxy)isonicotin-amide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.4 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.52 mmol of O-(tetrahydro-pyran-2-yl)-hydroxylamine. LC/MS [9.07 min; 458 (M+1)]

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08841459B2
출처 데이터셋uspto-grants-2014_09
ORD IDord-440f9f8e421a4ea796f0ffd497017a66
출처 메모uspto-grants-2014_09