O-Benzylhydroxylamine → N-(benzyloxy)-3-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

HRID 78845

반응식

HRID 78845 반응식
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[CH2:19]([O:26][NH2:27])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[CH2:19]([O:26][NH:27][C:12](=[O:14])[C:11]1[CH:15]=[CH:16][N:17]=[CH:18][C:10]=1[NH:9][C:3]1[CH:4]=[CH:5][C:6]([I:8])=[CH:7][C:2]=1[F:1])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

참가 물질

3

반응물 2

HCID 102313O-BenzylhydroxylamineHCID 590267913-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid2회

생성물 1

HCID 11503610N-(benzyloxy)-3-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

실험 절차

N-(benzyloxy)-3-[(2-fluoro-4-iodophenyl)amino]isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.5 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.72 mmol of O-benzyl-hydroxylamine. LC/MS [9.50 min; 464 (M+1)]

후처리

  1. customLC/MS [9.50 min; 464 (M+1)]

출처 및 근거

ORD 기록
ord-f194c69ad7ec4f07972f815e624a5f68
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841459B2

연결된 노트

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