Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Amino-2-ethyl-1,3-propanediol → N-(1,1-Bis-hydroxymethyl-propyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Amino-2-ethyl-1,3-propanediol | HCID 8282 | — |
| 반응물 | 3-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid | HCID 59026791 | — |
| 생성물 | N-(1,1-Bis-hydroxymethyl-propyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide | HCID 11518227 | — |
반응 단계
N-(1,1-Bis-hydroxymethyl-propyl)-3-(2-fluoro-4-iodo-phenylamino) -isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.33 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.47 mmol of 2-amino-2-ethyl-propane-1,3-diol. LC/MS [5.93 min; 460 (M+1)]
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841459B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-c4669fba41474d649e41e3967e51e743 |
| 출처 메모 | uspto-grants-2014_09 |