Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Iodo-o-toluidine → 2-Chloro-3-(2-fluoro-4-iodophenylamino)-isonicotinic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Iodo-o-toluidine | HCID 83221 | — |
| 반응물 | 3-Chloro-2-fluoropyridine-4-carboxylic acid | HCID 12175428 | — |
| 반응물 | 3-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid | HCID 59026791 | — |
| 생성물 | 2-Chloro-3-(2-fluoro-4-iodophenylamino)-isonicotinic acid | HCID 57649634 | — |
반응 단계
2-Chloro-3-(2-fluoro-4-iodo-phenylamino)-isonicotinic acid was synthesized as outlined in General Method 1 and according to the procedure for the synthesis of intermediate 1 by reacting 4 mmol of 2-methyl-4-iodoaniline with 6 mmol 2-fluoro-3-chloro-isonicotinic acid. LC/MS [10.25 min; 390.9 (M−1)-ESI-].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841459B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-711002fca8c649d4bb18a7cce41ecffc |
| 출처 메모 | uspto-grants-2014_09 |