Pyridinium chloride → 2-Butyl-6-fluoro-5-hydroxy-1-indanone

HRID 7888

반응식

HRID 7888 반응식
[CH2:1]([CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][C:9]([F:16])=[C:10]([O:14]C)[CH:11]=2)[C:6]1=[O:17])[CH2:2][CH2:3][CH3:4].Cl.N1C=CC=CC=1>>[CH2:1]([CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][C:9]([F:16])=[C:10]([OH:14])[CH:11]=2)[C:6]1=[O:17])[CH2:2][CH2:3][CH3:4]

참가 물질

3

반응물 2

HCID 10176127Pyridinium chlorideHCID 119529412-Butyl-6-fluoro-5-methoxy-1-indanone

생성물 1

HCID 219908852-Butyl-6-fluoro-5-hydroxy-1-indanone수율 95.1%

반응 조건

온도
200 °C

실험 절차

A mixture of 2-butyl-6-fluoro-5-methoxy-1-indanone (2.0 g) and pyridine hydrochloride (15.0 g) was heated in an oil bath at 200° C. for 75 minutes. After cooling to room temperature, the mixture was partitioned between EtOAc (100 mL) and water (75 mL) containing brine (25 mL). The organic phase was washed with brine (50 mL), dried over MgSO4, filtered, and evaporated under vacuum to provide 2-butyl-6-fluoro-5-hydroxy-1-indanone (1.79 g) as a solid.

후처리

  1. temperatureAfter cooling to room temperature
  2. customthe mixture was partitioned between EtOAc (100 mL) and water (75 mL)
  3. additioncontaining brine (25 mL)
  4. washThe organic phase was washed with brine (50 mL)
  5. dry with materialdried over MgSO4
  6. filtrationfiltered
  7. customevaporated under vacuum

출처 및 근거

ORD 기록
ord-1a97121dbeb748ada83910f7c64b7fb6
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087599B2

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