Benzene → 2-benzhydryl-3,4-dihydro-2H-pyran

HRID 78895

반응식

HRID 78895 반응식
C1([CH:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:8]([O:13][CH:14]=C)[CH2:9][CH2:10][CH:11]=C)C=CC=CC=1.[CH:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>Cl[Ru](=CC1C=CC=CC=1)([P](C1CCCCC1)(C1CCCCC1)C1CCCCC1)([P](C1CCCCC1)(C1CCCCC1)C1CCCCC1)Cl>[CH:7]([CH:8]1[CH2:9][CH2:10][CH:11]=[CH:14][O:13]1)([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

참가 물질

4

반응물 2

HCID 241BenzeneHCID 666312581,1-Diphenyl-2-(1-ethenoxy)-hex-5-ene

생성물 1

HCID 666312272-benzhydryl-3,4-dihydro-2H-pyran수율 92.6%

시약·촉매·용매 1

HCID 178479819HCID 178479819, 화합물촉매

실험 절차

A solution of 1,1-diphenyl-2-(1-ethenoxy)-hex-5-ene 9 (5.1 g, 18.3 mmol) and Grubb's catalyst (1.5 g, 1.83 mmol) in benzene (200 ml) was heated under reflux for 20 hr. The solvent was removed under vacuo and the residue was chromatographed over silica gel (Hexane/Ethyl Acetate 20:1) to give 2-diphenyl-3,4-dihydro-2H-pyran 10 (4.25 g, 92.6%) as a liquid.

후처리

  1. temperatureunder reflux for 20 hr
  2. customThe solvent was removed under vacuo
  3. customthe residue was chromatographed over silica gel (Hexane/Ethyl Acetate 20:1)

출처 및 근거

ORD 기록
ord-610562bf6af8475e806557347a3cbda5
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841464B2

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