Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → Cis-(6-benzhydryl-tetrahydropyran-3-yl)-(3,4-difluoro-benzyl)-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | 3,4-Difluorobenzaldehyde | HCID 588088 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 반응물 | Cis-(6-benzhydryl-tetrahydropyran-3-yl)-amine | HCID 11565229 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Cis-(6-benzhydryl-tetrahydropyran-3-yl)-(3,4-difluoro-benzyl)-amine | HCID 66631767 | 80.3% |
반응 단계
Trans-5-amino-2-diphenylmethyl-tetrahydropyran 15 (0.1 g, 0.38 mmol) was reacted with 3,4-difluorobenzaldehyde (0.055 g, 0.38 mmol) in the presence of glacial acetic acid (0.023 g, 0.38 mmol) in 1,2-dichloroethane (20 ml), and NaCNBH3 (0.03 g, 0.45 mmol) in methanol (5 ml) (Procedure D) to give compound 16j (0.12 g, 80%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841464B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-e60d72141e284ba6b0f9256b7410a83c |
| 출처 메모 | uspto-grants-2014_09 |