Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Fluorophenethylamine → (2S,4R,5R)-2-benzhydryl-5-[2-(4-fluorophenyl)-ethylamino]-tetrahydropyran-4-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Fluorophenethylamine | HCID 4653 | — |
| 반응물 | (1S,4S,6R)-4-benzhydryl-3,7-dioxa-bicyclo[4.1.0]-heptane | HCID 54762329 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | (2S,4R,5R)-2-benzhydryl-5-[2-(4-fluorophenyl)-ethylamino]-tetrahydropyran-4-ol | HCID 11315715 | — |
반응 단계
(1S,4S,6R)-4-benzhydryl-3,7-dioxa-bicyclo[4.1.0]-heptane 28a (0.025 g, 0.094 mmol) was reacted with 2-(4-fluoro-phenyl)-ethylamine (0.26 g, 1.88 mmol) in ethanol (Procedure E) to yield (2S,4R,5R)-2-benzhydryl-5-[2-(4-fluorophenyl)-ethylamino]-tetrahydropyran-4-ol, (−)-29c, 0.04 g (98%, [α]D=(−)62.9, c=1, MeOH).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841464B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-436e06b4e72843c5bb0ba028063952e6 |
| 출처 메모 | uspto-grants-2014_09 |