1-(3-Fluoro-4-methylphenyl)ethanol → 1-(3-Fluoro-4-methylphenyl)ethan-1-one

HRID 7908

반응식

HRID 7908 반응식
[OH:1][CH:2]([C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[C:6]([F:11])[CH:5]=1)[CH3:3].C1C=C[NH+]=CC=1.[O-][Cr](Cl)(=O)=O>C(Cl)Cl>[F:11][C:6]1[CH:5]=[C:4]([C:2](=[O:1])[CH3:3])[CH:9]=[CH:8][C:7]=1[CH3:10]

참가 물질

4

반응물 2

HCID 219913931-(3-Fluoro-4-methylphenyl)ethanolHCID 178418287HCID 178418287, 화합물

생성물 1

HCID 27745691-(3-Fluoro-4-methylphenyl)ethan-1-one수율 86.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-(1-hydroxyethyl)-2-fluorotoluene (55.8 mg, 0.36 mmol) in methylene chloride (1 mL) were added molecular sieve 4A (56.0 mg) and PCC 94.0 mg (0.43 mmol), and the mixture was stirred at room temperature for 1 hour. The reaction mixture was filtered through Celite, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel to yield the title compound as a pale yellow oil (47.5 mg, 86.0%).

후처리

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe residue was purified by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-0498ef0e78694a75a5377ea196575744
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087606B2

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