Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzenesulfonamide, 3-amino- → N-(3-sulfamoylphenyl)-4-(trifluoromethoxy)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzenesulfonamide, 3-amino- | HCID 7377 | — |
| 반응물 | 4-(Trifluoromethoxy)benzoyl Chloride | HCID 142110 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | N-(3-sulfamoylphenyl)-4-(trifluoromethoxy)benzamide | HCID 4784511 | — |
반응 단계
To a solution of 3-amino-benzenesulfonamide (17 mg, 0.10 mmol) in pyridine (1 mL) was added 4-trifluoromethoxy benzoyl chloride (16 μL, 0.10 mmol). The reaction was stirred at room temperature for 15 h and purified by preparative reverse phase HPLC using 10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA) to give N-(3-(aminosulfonyl)phenyl)-4-(trifluoromethoxy)benzamide. LC/MS: m/z 360.9 (M+H)+ at 3.02 min (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841483B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-0ad32f6959f3494a890a8ff7c4c23a47 |
| 출처 메모 | uspto-grants-2014_09 |