Tetrahydrofuran → tert-Butyl 4-(6-((8-chloro-9-cyclopentyl-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]-pyrimidin-2-yl)amino)-3-pyridinyl)-1-piperazinecarboxylate

반응식

Br[C:2]1[N:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[Cl:21][C:22]1[C:27]2[N:28]([CH:36]3[CH2:40][CH2:39][CH2:38][CH2:37]3)[C:29]3[N:30]=[C:31]([NH2:35])[N:32]=[CH:33][C:34]=3[C:26]=2[CH:25]=[CH:24][N:23]=1.[Li+].C[Si]([N-][Si](C)(C)C)(C)C.C1COCC1.C1(P(C2C=CC=CC=2)C2C3OC4C(=CC=CC=4P(C4C=CC=CC=4)C4C=CC=CC=4)C(C)(C)C=3C=CC=2)C=CC=CC=1.[NH4+].[Cl-]>C1(C)C=CC=CC=1.C(Cl)Cl.CO.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[Cl:21][C:22]1[C:27]2[N:28]([CH:36]3[CH2:40][CH2:39][CH2:38][CH2:37]3)[C:29]3[N:30]=[C:31]([NH:35][C:2]4[N:7]=[CH:6][C:5]([N:8]5[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH2:9]5)=[CH:4][CH:3]=4)[N:32]=[CH:33][C:34]=3[C:26]=2[CH:25]=[CH:24][N:23]=1