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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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tert-Butyl piperazine-1-carboxylate → tert-butyl 4-((6-((3-ethyl-4-(imidazo[1,2-a]pyridine-3-carboxamido)-1H-indazol-1-yl)methyl)pyridin-2-yl)methyl)piperazine-1-carboxylate

HRID 79291
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HRID 79291 반응식
[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[NH:12][C:13]([C:15]2[N:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]3=[N:17][CH:16]=2)=[O:14])[N:5]([CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([CH:31]=O)[N:26]=2)[N:4]=1)[CH3:2].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].[N:47]1([C:53]([O:55][C:56]([CH3:59])([CH3:58])[CH3:57])=[O:54])[CH2:52][CH2:51][NH:50][CH2:49][CH2:48]1>ClCCl.CO>[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[NH:12][C:13]([C:15]2[N:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]3=[N:17][CH:16]=2)=[O:14])[N:5]([CH2:24][C:25]2[N:26]=[C:27]([CH2:31][N:50]3[CH2:51][CH2:52][N:47]([C:53]([O:55][C:56]([CH3:59])([CH3:58])[CH3:57])=[O:54])[CH2:48][CH2:49]3)[CH:28]=[CH:29][CH:30]=2)[N:4]=1)[CH3:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 5049666Sodium triacetoxyborohydrideHCID 86672209N-(3-ethyl-1-((6-formylpyridin-2-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide

생성물 1

HCID 67261333tert-butyl 4-((6-((3-ethyl-4-(imidazo[1,2-a]pyridine-3-carboxamido)-1H-indazol-1-yl)methyl)pyridin-2-yl)methyl)piperazine-1-carboxylate수율 45%

시약·촉매·용매 1

HCID 21226129Dichloromethane methanol용매

실험 절차

To a mixture of N-(3-ethyl-1-((6-formylpyridin-2-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide (20 mg, 0.0471 mmol) and sodium triacetoxyborohydride (49.9 mg, 0.236 mmol) in a 1:1 mixture of dichloromethane/methanol (1 mL) was added tert-butyl piperazine-1-carboxylate (10.5 mg, 0.0565 mmol). The mixture was stirred for 30 minutes at ambient temperature. The solvent was removed under reduced pressure and the residue was purified using preparative thin layer chromatography on silica, eluting with 12% methanol and 0.5% ammonium hydroxide in dichloromethane to give the desired product (12.6 mg).

후처리

  1. customThe solvent was removed under reduced pressure
  2. customthe residue was purified
  3. washeluting with 12% methanol and 0.5% ammonium hydroxide in dichloromethane

출처 및 근거

ORD 기록
ord-739eef8958d74bdebd0ceda2c7add3ef
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08841455B2

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