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Sodium sulfate decahydrate → (6-Methoxypyridin-2-yl)methanol

HRID 79293
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HRID 79293 반응식
[CH3:1][O:2][C:3]1[N:8]=[C:7]([C:9](OC)=[O:10])[CH:6]=[CH:5][CH:4]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3].O.O.O.O.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Na+].[Na+]>CCOCC>[CH3:1][O:2][C:3]1[N:8]=[C:7]([CH2:9][OH:10])[CH:6]=[CH:5][CH:4]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 62649Sodium sulfate decahydrateHCID 16218333Methyl 6-methoxypyridine-2-carboxylateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 12325389(6-Methoxypyridin-2-yl)methanol수율 86.9%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To methyl 6-methoxypicolinate (4.65 g, 27.8 mmol) in Et2O (100 mL) was added LAH (1.06 g). The reaction mixture was stirred for 4 hours. Celite (10 g) was added, followed by sodium sulfate-decahydrate (5 g). The reaction mixture was filtered and concentrated to provide the desired product (3.36 g).

후처리

  1. additionCelite (10 g) was added
  2. filtrationThe reaction mixture was filtered
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b27c41fc331140c3b665b704143aa163
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08841455B2

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