1-((6-methoxypyridin-2-yl)methyl)-4-nitro-3-vinyl-1H-indazole → 3-ethyl-1-((6-methoxypyridin-2-yl)methyl)-1H-indazol-4-amine

HRID 79297

반응식

HRID 79297 반응식
[CH3:1][O:2][C:3]1[N:8]=[C:7]([CH2:9][N:10]2[C:18]3[C:13](=[C:14]([N+:19]([O-])=O)[CH:15]=[CH:16][CH:17]=3)[C:12]([CH:22]=[CH2:23])=[N:11]2)[CH:6]=[CH:5][CH:4]=1>CO.[OH-].[OH-].[Pd+2]>[CH2:22]([C:12]1[C:13]2[C:14]([NH2:19])=[CH:15][CH:16]=[CH:17][C:18]=2[N:10]([CH2:9][C:7]2[CH:6]=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[N:8]=2)[N:11]=1)[CH3:23]

참가 물질

4

반응물 1

HCID 672600471-((6-methoxypyridin-2-yl)methyl)-4-nitro-3-vinyl-1H-indazole

생성물 1

HCID 672592283-ethyl-1-((6-methoxypyridin-2-yl)methyl)-1H-indazol-4-amine수율 79.1%

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 887Methanol용매

실험 절차

To 1-((6-methoxypyridin-2-yl)methyl)-4-nitro-3-vinyl-1H-indazole (1.89 g, 6.09 mmol) in MeOH (60 mL) was added Pd(OH)2/C (20 wt %, 400 mg). The reaction mixture was purged with N2 and charge with H2 (45 psi). The reaction mixture was recharged H2 to 45 psi after 45 minute. The reaction was stopped after 5 hours. The reaction mixture was filtered through Celite®, washed with MeOH (200 mL) and concentrated to provide the desired product (1.36 g).

후처리

  1. customThe reaction mixture was purged with N2
  2. additioncharge with H2 (45 psi)
  3. customafter 45 minute
  4. filtrationThe reaction mixture was filtered through Celite®
  5. washwashed with MeOH (200 mL)
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a228aba76530405ab6f4c68bf6c1a722
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841455B2

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