Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Methylpiperazine → 6-(3-fluoro-4-methoxyphenyl)-2-isobutyl-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Methylpiperazine | HCID 53167 | — |
| 반응물 | (3-fluoro-4-methoxyphenyl)-2-isobutyl-4-methane-sulfonylo xy-methyl-2H-pyridazin-3-one | HCID 21991399 | — |
| 반응물 | 4-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one | HCID 67214099 | — |
| 생성물 | 6-(3-fluoro-4-methoxyphenyl)-2-isobutyl-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-one | HCID 21991503 | 80.9% |
반응 단계
Following the procedure of Example 1 (10), 6-(3-fluoro-4-methoxyphenyl)-2-isobutyl-4-methanesulfonyloxy-methyl-2H-pyridazin-3-one and 1-methylpiperazine were reacted to yield the title compound as a yellow oil (yield: 80.9%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07087606B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-9a890b21ea1b4a5fba0835c8a826d216 |
| 출처 메모 | uspto-grants-2006_08 |