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Trifluoroacetic acid → N-(3-ethyl-1-((6-(piperidin-4-yloxy)pyridin-2-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide

HRID 79307
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HRID 79307 반응식
[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[NH:12][C:13]([C:15]2[N:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]3=[N:17][CH:16]=2)=[O:14])[N:5]([CH2:24][C:25]2[N:30]=[C:29]([O:31][CH:32]3[CH2:37][CH2:36][N:35](C(OC(C)(C)C)=O)[CH2:34][CH2:33]3)[CH:28]=[CH:27][CH:26]=2)[N:4]=1)[CH3:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[NH:12][C:13]([C:15]2[N:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]3=[N:17][CH:16]=2)=[O:14])[N:5]([CH2:24][C:25]2[CH:26]=[CH:27][CH:28]=[C:29]([O:31][CH:32]3[CH2:33][CH2:34][NH:35][CH2:36][CH2:37]3)[N:30]=2)[N:4]=1)[CH3:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 67261312tert-butyl 4-(6-((3-ethyl-4-(imidazo[1,2-a]pyridine-3-carboxamido)-1H-indazol-1-yl)methyl)pyridin-2-yloxy)piperidine-1-carboxylate

생성물 1

HCID 67259706N-(3-ethyl-1-((6-(piperidin-4-yloxy)pyridin-2-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide수율 20.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To tert-butyl 4-(6-((3-ethyl-4-(imidazo[1,2-a]pyridine-3-carboxamido)-1H-indazol-1-yl)methyl)pyridin-2-yloxy)piperidine-1-carboxylate (3 mg, 0.02 mmol) in DCM (1 mL) was added TFA (1 mL). The reaction mixture was stirred for one hour and concentrated. Silica gel chromatography of the crude material (DCM/MeOH/NH4OH 10:1:0.1) provided the desired product (2 mg). MS (ES+APCI) m/z=496 (M+H).

후처리

  1. concentrationconcentrated

출처 및 근거

ORD 기록
ord-df6b16446f0b4678be58f22aa1c486a6
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08841455B2

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