반응식
C(C1C2C(=CC=CC=2N[C:13](C2N3C=CC=CC3=NC=2)=[O:14])N(CC2C=NN([C@@H]3CCNC[C@H]3F)C=2)[N:4]=1)C.[CH2:37]([C:39]1[C:47]2[C:42](=[CH:43][CH:44]=[CH:45][C:46]=2[NH:48][C:49]([C:51]2[N:55]3[CH:56]=[CH:57][CH:58]=[CH:59][C:54]3=[N:53][CH:52]=2)=[O:50])[N:41]([CH2:60][C:61]2[CH:62]=[N:63][N:64]([C@@H:66]3[CH2:71][CH2:70][N:69](C(OC(C)(C)C)=O)[CH2:68][C@H:67]3[F:79])[CH:65]=2)[N:40]=1)[CH3:38].C(O)(C(F)(F)F)=O.[CH2:87]([Cl:89])[Cl:88]>>[CH2:87]([Cl:89])[Cl:88].[CH3:13][OH:14].[NH4+:4].[OH-:50].[CH2:37]([C:39]1[C:47]2[C:42](=[CH:43][CH:44]=[CH:45][C:46]=2[NH:48][C:49]([C:51]2[N:55]3[CH:56]=[CH:57][CH:58]=[CH:59][C:54]3=[N:53][CH:52]=2)=[O:50])[N:41]([CH2:60][C:61]2[CH:62]=[N:63][N:64]([C@@H:66]3[CH2:71][CH2:70][NH:69][CH2:68][C@H:67]3[F:79])[CH:65]=2)[N:40]=1)[CH3:38]참가 물질
6
반응물 4
HCID 6344Dichloromethane
HCID 6422Trifluoroacetic acid
HCID 67259695N-(3-ethyl-1-((1-((3R,4R)-3-fluoropiperidin-4-yl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide
HCID 70814963(3R,4R)-tert-butyl 4-(4-((3-ethyl-4-(imidazo[1,2-a]pyridine-3-carboxamido)-1H-indazol-1-yl)methyl)-1H-pyrazol-1-yl)-3-fluoropiperidine-1-carboxylate생성물 2
실험 절차
Preparation of N-(3-ethyl-1-((1-((3R,4R)-3-fluoropiperidin-4-yl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide]: To (3R,4R)-tert-butyl 4-(4-((3-ethyl-4-(imidazo[1,2-a]pyridine-3-carboxamido)-1H-indazol-1-yl)methyl)-1H-pyrazol-1-yl)-3-fluoropiperidine-1-carboxylate (7 mg, 0.01 mmol) in DCM (2 mL) was added TFA (1 mL). The reaction mixture was stirred for 30 minutes, concentrated and silica gel chromatography (DCM/MeOH/NH4OH 10:1:0.1) gave the final product (3 mg). MS (ES+APCI) m/z=487 (M+H).
후처리
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-278158b939ea421c9214b502ed029f5d
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08841455B2
연결된 노트
불러오는 중…