6-(3-fluoro-4-methylphenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-one → 2-isobutyl-4-methoxycarbonyl-6-phenyl-2H-pyridazin-3-one

HRID 7932노트

반응식

HRID 7932 반응식
F[C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[C:11]([C:20]([O:22][CH3:23])=[O:21])[C:12](=[O:19])[N:13]([CH2:15][CH:16]([CH3:18])[CH3:17])[N:14]=2)[CH:5]=[CH:6][C:7]=1C.COC(C1C(=O)NN=C(C2C=CC=CC=2)C=1)=O>>[CH2:15]([N:13]1[C:12](=[O:19])[C:11]([C:20]([O:22][CH3:23])=[O:21])=[CH:10][C:9]([C:4]2[CH:3]=[CH:2][CH:7]=[CH:6][CH:5]=2)=[N:14]1)[CH:16]([CH3:18])[CH3:17]

참가 물질

3

반응물 2

HCID 219914926-(3-fluoro-4-methylphenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-oneHCID 21991548Methyl 3-oxo-6-phenyl-2,3-dihydropyridazine-4-carboxylate

생성물 1

HCID 219916122-isobutyl-4-methoxycarbonyl-6-phenyl-2H-pyridazin-3-one수율 94.1%

실험 절차

Following the procedure of Example 1 (6), 4-methoxycarbonyl-6-phenyl-2H-pyridazin-3-one was reacted to yield the title compound as a yellow oil (yield: 94.1%).

후처리

  1. customwas reacted

출처 및 근거

ORD 기록
ord-0095c865a56e4289b73179372c43aea2
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087606B2

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