Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → Dichloromethane methanol ammonium hydroxide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | tert-butyl 4-((3-(3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-ylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)methyl)piperazine-1-carboxylate | HCID 70814959 | — |
| 생성물 | Dichloromethane methanol ammonium hydroxide | HCID 21896990 | — |
| 생성물 | N-(3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-yl)-7-(piperazin-1-ylmethyl)imidazo[1,2-a]pyridine-3-carboxamide | HCID 67260131 | — |
반응 단계
To tert-butyl 4-((3-(3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-ylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)methyl)piperazine-1-carboxylate (11 mg, 0.018 mmol) in DCM (1 mL) was added TFA (1 mL). The reaction mixture was stirred for 30 minutes, and then concentrated under reduced pressure. Silica gel chromatography (DCM/MeOH/NH4OH 10:1:0.1) provided the final product (6 mg). MS (ES+APCI) m/z=509 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841455B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-5df34623653440cc908d46d42259e0e9 |
| 출처 메모 | uspto-grants-2014_09 |