Potassium Carbonate → 3-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-5-yl)methyl)-4-nitro-1H-indazole

HRID 79340노트

반응식

HRID 79340 반응식
[I:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[N+:11]([O-:13])=[O:12])[NH:4][N:3]=1.Br[CH2:15][C:16]1[N:20]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=2)[N:19]=[CH:18][CH:17]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.CCOC(C)=O>[I:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[N+:11]([O-:13])=[O:12])[N:4]([CH2:15][C:16]2[N:20]([CH2:21][C:22]3[CH:23]=[CH:24][C:25]([O:28][CH3:29])=[CH:26][CH:27]=3)[N:19]=[CH:18][CH:17]=2)[N:3]=1

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 672614135-(bromomethyl)-1-(4-methoxybenzyl)-1H-pyrazoleHCID 178526562HCID 178526562, 화합물

생성물 1

HCID 672610463-iodo-1-((1-(4-methoxybenzyl)-1H-pyrazol-5-yl)methyl)-4-nitro-1H-indazole수율 89.4%

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

To 3-iodo-4-nitro-1H-indazole (1.55 g, 5.37 mmol) in DMF (20 mL) was added 5-(bromomethyl)-1-(4-methoxybenzyl)-1H-pyrazole (1.51 g, 5.37 mmol) and K2CO3 (1.11 g, 8.06 mmol). The reaction mixture was stirred overnight, diluted with EtOAc (100 mL), washed with H2O and brine (10 mL), and then concentrated under reduced pressure. Silica gel chromatography (Hexanes/EtOAc 5:1) provided the desired product (2.35 g).

후처리

  1. washwashed with H2O and brine (10 mL)
  2. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-315d07067760471fb7d6f5768a2b2ab6
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841455B2

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