1-((6-methylpyridin-2-yl)methyl)-4-nitro-3-vinyl-1H-indazole → 3-ethyl-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-amine

HRID 79354

반응식

HRID 79354 반응식
[CH3:1][C:2]1[N:7]=[C:6]([CH2:8][N:9]2[C:17]3[C:12](=[C:13]([N+:18]([O-])=O)[CH:14]=[CH:15][CH:16]=3)[C:11]([CH:21]=[CH2:22])=[N:10]2)[CH:5]=[CH:4][CH:3]=1>CO.[OH-].[OH-].[Pd+2]>[CH2:21]([C:11]1[C:12]2[C:13]([NH2:18])=[CH:14][CH:15]=[CH:16][C:17]=2[N:9]([CH2:8][C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([CH3:1])[N:7]=2)[N:10]=1)[CH3:22]

참가 물질

4

반응물 1

HCID 672597031-((6-methylpyridin-2-yl)methyl)-4-nitro-3-vinyl-1H-indazole

생성물 1

HCID 672598043-ethyl-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-amine수율 97.5%

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 887Methanol용매2회

실험 절차

A mixture of 1-((6-methylpyridin-2-yl)methyl)-4-nitro-3-vinyl-1H-indazole (161 mg, 0.547 mmol) and 20% palladium hydroxide on carbon (38.4 mg, 0.0547 mmol) was stirred in methanol (3 mL) under an atmosphere of hydrogen for 3 hours. The mixture was diluted with methanol and filtered through glass fiber filter paper. The filtrate was concentrated under reduced pressure to give 3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-amine (142 mg).

후처리

  1. filtrationfiltered through glass fiber
  2. filtrationfilter paper
  3. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-7e41cdeb398a41c0a5224d07d3641cd7
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841455B2

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