Tetrahydrofuran → HCID 86672213, 화합물

HRID 79361노트

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HRID 79361 반응식
[CH3:1][O:2][C:3]1[N:12]=[C:11]([CH3:13])[CH:10]=[CH:9][C:4]=1[C:5]([O:7]C)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.O.O.O.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Na+].[Na+].[CH2:37]1COC[CH2:38]1>>[CH2:37]([CH:5]([C:4]1[C:3]([O:2][CH3:1])=[N:12][C:11]([CH3:13])=[CH:10][CH:9]=1)[OH:7])[CH3:38]

참가 물질

5

반응물 4

HCID 8028Tetrahydrofuran2회HCID 62649Sodium sulfate decahydrateHCID 10910170METHYL 2-METHOXY-6-METHYLPYRIDINE-3-CARBOXYLATEHCID 21226445Aluminium lithium hydride

생성물 1

HCID 86672213HCID 86672213, 화합물

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온도
0 °C

실험 절차

To methyl 2-methoxy-6-methylnicotinate (5.60 g, 30.9 mmol) in THF (155 mL, 30.9 mmol) to 0° C. was added lithium aluminum hydride (1.23 g, 30.9 mmol) and the mixture was stirred at 0° C. for 75 minutes. The mixture was diluted with 30 mL THF and a scoop of Celite was added. The mixture was stirred for a few minutes. Sodium sulfate decahydrate was added to quench the reaction. The mixture was filtered and the filtrate was concentrated to give the product (4.7 g).

후처리

  1. additiona scoop of Celite was added
  2. stirringThe mixture was stirred for a few minutes
  3. customto quench
  4. customthe reaction
  5. filtrationThe mixture was filtered
  6. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-a20c86094b5b4575acd71a23ee8ea2fb
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841455B2

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