Thionyl Chloride → 3-(chloromethyl)-1-isopropyl-1H-pyrazole hydrochloride

HRID 79394노트

반응식

HRID 79394 반응식
[CH:1]([N:4]1[CH:8]=[CH:7][C:6]([CH2:9]O)=[N:5]1)([CH3:3])[CH3:2].S(Cl)([Cl:13])=O>C(Cl)Cl>[ClH:13].[Cl:13][CH2:9][C:6]1[CH:7]=[CH:8][N:4]([CH:1]([CH3:3])[CH3:2])[N:5]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 23005538(1-(propan-2-yl)-1H-pyrazol-3-yl)methanol

생성물 1

HCID 672599053-(chloromethyl)-1-isopropyl-1H-pyrazole hydrochloride수율 85.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (1-isopropyl-1H-pyrazol-3-yl)methanol (3.45 g, 24.61 mmol) in DCM (50 mL) was added thionyl chloride (5.386 mL, 73.83 mmol) at ambient temperature. The mixture was allowed to stir at ambient temperature for 18 hours. The mixture was concentrated under vacuum to afford 3-(chloromethyl)-1-isopropyl-1H-pyrazole hydrochloride (4.1 g, 85% yield) as a yellow gum.

후처리

  1. concentrationThe mixture was concentrated under vacuum

출처 및 근거

ORD 기록
ord-e169da713b8f4be4a67f53fa164ab8a4
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841455B2

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