Solketal → (2,2-Dimethyl-1,3-dioxolan-4-yl)methyl methanesulfonate
반응식
[CH3:1][C:2]1([CH3:9])[O:6][CH:5]([CH2:7][OH:8])[CH2:4][O:3]1.[CH3:10][S:11](Cl)(=[O:13])=[O:12].C(N(CC)CC)C>C(Cl)Cl>[CH3:10][S:11]([O:8][CH2:7][CH:5]1[CH2:4][O:3][C:2]([CH3:9])([CH3:1])[O:6]1)(=[O:13])=[O:12]참가 물질
5
실험 절차
To (2,2-dimethyl-1,3-dioxolan-4-yl)methanol (400 mg, 3.03 mmol) in DCM (6 mL) at 0° C. was added methanesulfonyl chloride (381 mg, 3.33 mmol) and triethylamine (368 mg, 3.63 mmol. The cold bath was removed and the reaction mixture was stirred for 30 minutes. The mixture was diluted with DCM (5 mL). The organic phase was washed with water (4 mL) and brine (2 mL), and dried (Na2SO4). The solution was concentrated under reduced pressure to give the product (642 mg).
후처리
- customThe cold bath was removed
- additionThe mixture was diluted with DCM (5 mL)
- washThe organic phase was washed with water (4 mL) and brine (2 mL)
- dry with materialdried (Na2SO4)
- concentrationThe solution was concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-c6973e2a5d534758b3d1c9b5b6305e53
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08841455B2
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