참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Solketal | HCID 7528 | — |
| 반응물 | 2-Amino-4-chloropyridine | HCID 581866 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-((2,2-Dimethyl-1,3-dioxolan-4-yl)methoxy)pyridin-2-amine | HCID 50987595 | 80% |
반응 단계
A sealed tube containing 4-chloro-2-pyridinamine (4 g, 31.2 mmol), (2,2-dimethyl-1,3-dioxolan-4-yl)methanol (8.4 g, 60.6 mmol), and sodium (1.46 g, 63.5 mmol) was heated at 145° C. for 8 hours. The mixture was cooled to ambient temperature; water (25 mL) and dichloromethane (50 mL) were added. The organic phase was separated, dried with sodium sulfate, and concentrated under reduced pressure. The resulting residue was purified by chromatography on silica-gel to give 4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)pyridin-2-amine as a pale yellow solid (5.6 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08841455B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-5231720e43f441fda1d0c65964eaca65 |
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| 출처 메모 | uspto-grants-2014_09 |
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