Potassium Carbonate → 4-((3-bromo-4-nitro-1H-indazol-1-yl)methyl)-2-methyloxazole

HRID 79461노트

반응식

HRID 79461 반응식
[Br:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[N+:11]([O-:13])=[O:12])[NH:4][N:3]=1.C([O-])([O-])=O.[K+].[K+].Br[CH2:21][C:22]1[N:23]=[C:24]([CH3:27])[O:25][CH:26]=1>CN(C=O)C.O>[Br:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[N+:11]([O-:13])=[O:12])[N:4]([CH2:21][C:22]2[N:23]=[C:24]([CH3:27])[O:25][CH:26]=2)[N:3]=1

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 441196044-(Bromomethyl)-2-methyloxazoleHCID 178526560HCID 178526560, 화합물

생성물 1

HCID 672615694-((3-bromo-4-nitro-1H-indazol-1-yl)methyl)-2-methyloxazole수율 43.6%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매2회

실험 절차

A suspension of 3-bromo-4-nitro-1H-indazole (Preparation B; 500 mg, 2.07 mmol) and K2CO3 (1.14 g, 8.26 mmol) in anhydrous DMF (3 mL) was treated at ambient temperature, under a nitrogen atmosphere, with a solution of 4-(bromomethyl)-2-methyloxazole (727 mg, 2.07 mmol) (Org. Biom. Chem., 2003, 1, 4173-4208) in anhydrous DMF (2 mL). The reaction mixture was stirred at ambient temperature for 16 hours. The reaction mixture was diluted with excess water and extracted multiple times with DCM and EtOAc. The combined extracts were dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the crude product (0.5 g). The material was purified by preparative thin-layer chromatography (silica, 5% MeOH-DCM as eluent) to afford the product (304 mg) as a solid.

후처리

  1. extractionextracted multiple times with DCM and EtOAc
  2. dry with materialThe combined extracts were dried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure
  4. customto afford the crude product (0.5 g)
  5. customThe material was purified by preparative thin-layer chromatography (silica, 5% MeOH-DCM as eluent)

출처 및 근거

ORD 기록
ord-fc7e86bbac614ccf843ec485b2fddcb2
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841455B2

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