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Imidazole → 1-((5-(tert-butyldimethylsilyloxy)-6-methylpyridin-2-yl)methyl)-3-cyclopropyl-1H-indazol-4-amine

HRID 79485
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HRID 79485 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([CH:20]1[CH2:22][CH2:21]1)=[N:5][N:6]2[CH2:11][C:12]1[N:17]=[C:16]([CH3:18])[C:15]([OH:19])=[CH:14][CH:13]=1.[C:23]([Si:27](Cl)([CH3:29])[CH3:28])([CH3:26])([CH3:25])[CH3:24].N1C=CN=C1>CN(C=O)C>[Si:27]([O:19][C:15]1[CH:14]=[CH:13][C:12]([CH2:11][N:6]2[C:7]3[CH:8]=[CH:9][CH:10]=[C:2]([NH2:1])[C:3]=3[C:4]([CH:20]3[CH2:22][CH2:21]3)=[N:5]2)=[N:17][C:16]=1[CH3:18])([C:23]([CH3:26])([CH3:25])[CH3:24])([CH3:29])[CH3:28]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 28928tert-Butyldimethylsilyl chlorideHCID 67251409HCID 67251409, 화합물

생성물 1

HCID 672532771-((5-(tert-butyldimethylsilyloxy)-6-methylpyridin-2-yl)methyl)-3-cyclopropyl-1H-indazol-4-amine수율 97%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To 6-((4-amino-3-cyclopropyl-1H-indazol-1-yl)methyl)-2-methylpyridin-3-ol (100 mg, 0.340 mmol) in DMF (5 mL) was added tert-butylchlorodimethylsilane (66.6 mg, 0.442 mmol) and 1H-imidazole (116 mg, 1.70 mmol). The reaction mixture was stirred for 18 hours at ambient temperature. The solvent was removed under reduced pressure, and the residue was purified by silica gel flash chromatography (1:4 EtOAc/hexanes) to give final product (97%).

후처리

  1. customThe solvent was removed under reduced pressure
  2. customthe residue was purified by silica gel flash chromatography (1:4 EtOAc/hexanes)

출처 및 근거

ORD 기록
ord-df39c32a0a9d4cb19b011c976eb96a43
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08841455B2

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