Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Dimethoxyethane → 7-Azaindole N-oxide 3-chlorobenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 반응물 | 1H-Pyrrolo(2,3-b)pyridine | HCID 9222 | — |
| 반응물 | m-Chloroperbenzoic acid | HCID 70297 | — |
| 용매 | Heptane | HCID 8900 | — |
| 생성물 | 7-Azaindole N-oxide 3-chlorobenzoate | HCID 11572863 | 89.4% |
반응 단계
meta-Chloroperbenzoic acid (“m-CPBA”; 25.4 g, 147 mmol) was added portionwise to 1H-pyrrolo[2,3-b]pyridine (15.0 g, 127 mmol) in 1:2 dimethoxyethane (“DME”):heptane (80:160 mL) at 10° C. The reaction was then stirred at room temperature for 1 hour. The precipitate was filtered and washed with 1:2 DME:heptane. The precipitate was then dried to give 7-hydroxy-1H-pyrrolo[2,3-b]pyridin-7-ium 3-chlorobenzoate (33.0 g, 89.4% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841304B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-3ad0b0570cd948589fc657a1adacabd3 |
| 출처 메모 | uspto-grants-2014_09 |