Ethyl 4-(3,4-difluorophenyl)-2-ethoxycarbonyl-2-hydroxy-4-oxo-butanoate → 4-carboxy-6-(3,4-difluorophenyl)-2H-pyridazin-3-one

HRID 7960노트

반응식

HRID 7960 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:19]([O:21]C)=[O:20])[C:11](=[O:18])[N:12](CC(C)C)[N:13]=2)=[CH:4][C:3]=1C.[F:24]C1C=C(C(=O)CC(C(OCC)=O)(O)C(OCC)=O)C=CC=1F>>[C:19]([C:10]1[C:11](=[O:18])[NH:12][N:13]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[C:3]([F:24])[CH:4]=2)[CH:9]=1)([OH:21])=[O:20]

참가 물질

3

반응물 2

HCID 21991446Ethyl 4-(3,4-difluorophenyl)-2-ethoxycarbonyl-2-hydroxy-4-oxo-butanoateHCID 219915336-(4-fluoro-3-methylphenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-one

생성물 1

HCID 219916754-carboxy-6-(3,4-difluorophenyl)-2H-pyridazin-3-one수율 88.9%

실험 절차

Following the procedure of Example 1 (4), ethyl 4-(3,4-difluorophenyl)-2-ethoxycarbonyl-2-hydroxy-4-oxo-butanoate was reacted to yield the title compound as a pale yellow crystalline powder (yield: 88.9%).

후처리

  1. customwas reacted

출처 및 근거

ORD 기록
ord-c8bc44c09c944120ae7f421e56636c18
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087606B2

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