4-carboxy-6-(3,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one → 6-(2,4-difluorophenyl)-4-methoxycarbonyl-2H-pyridazin-3-one

HRID 7968

반응식

HRID 7968 반응식
[C:1](C1C(=O)N(CC(C)C)N=C(C2C=CC(F)=C(F)C=2)C=1)(O)=O.[C:23]([C:26]1[C:27](=[O:40])[NH:28][N:29]=[C:30]([C:32]2[CH:37]=[CH:36][C:35]([F:38])=[CH:34][C:33]=2[F:39])[CH:31]=1)([OH:25])=[O:24]>>[F:39][C:33]1[CH:34]=[C:35]([F:38])[CH:36]=[CH:37][C:32]=1[C:30]1[CH:31]=[C:26]([C:23]([O:25][CH3:1])=[O:24])[C:27](=[O:40])[NH:28][N:29]=1

참가 물질

3

반응물 2

HCID 219916384-carboxy-6-(3,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-oneHCID 219916774-carboxy-6-(2,4-difluorophenyl)-2H-pyridazin-3-one

생성물 1

HCID 219916986-(2,4-difluorophenyl)-4-methoxycarbonyl-2H-pyridazin-3-one수율 81.2%

실험 절차

Following the procedure of Example 1 (5), 4-carboxy-6-(2,4-difluorophenyl)-2H-pyridazin-3-one was reacted to yield the title compound as a pale yellow crystalline powder (yield: 81.2%).

후처리

  1. customwas reacted

출처 및 근거

ORD 기록
ord-ae39ca789a344dbc8de31b5a25116b20
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087606B2

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