4-carboxy-6-(2,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one → 6-(2,4-difluorophenyl)-4-hydroxymethyl-2-isobutyl-2H-pyridazin-3-one
반응식
C(OC(N1CCN(C2C(=O)N(CC(C)C)N=C(C3C=CC(F)=C(F)C=3)C=2C)CC1)=O)(C)(C)C.[C:34]([C:37]1[C:38](=[O:55])[N:39]([CH2:51][CH:52]([CH3:54])[CH3:53])[N:40]=[C:41]([C:43]2[CH:48]=[CH:47][C:46]([F:49])=[CH:45][C:44]=2[F:50])[CH:42]=1)(O)=[O:35]>>[F:50][C:44]1[CH:45]=[C:46]([F:49])[CH:47]=[CH:48][C:43]=1[C:41]1[CH:42]=[C:37]([CH2:34][OH:35])[C:38](=[O:55])[N:39]([CH2:51][CH:52]([CH3:53])[CH3:54])[N:40]=1참가 물질
3
실험 절차
Following the procedure of Example 1 (8), 4-carboxy-6-(2,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one was reacted to yield the title compound as a pale yellow oil (yield: 45.0%).
후처리
- customwas reacted