Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Oxalyl chloride → Benzyl 4-(chlorocarbonyl)piperidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 반응물 | 1-Carbobenzoxy-4-piperidinecarboxylic Acid | HCID 736489 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Benzyl 4-(chlorocarbonyl)piperidine-1-carboxylate | HCID 2776270 | 101.8% |
반응 단계
Piperidine-1,4-dicarboxylic acid monobenzyl ester (40.2 g, 0.15 mol) in dichloromethane (300 mL) was treated with oxalyl chloride (100 g, 0.79 mol). The reaction mixture was stirred at ambient temperature for 4 hours and the mixture was concentrated to afford crude 4-chlorocarbonyl-piperidine-1-carboxylic acid benzyl ester (43 g), which was used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841278B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-e041540c78f04ed5ae40a2c74ef0a5c9 |
| 출처 메모 | uspto-grants-2014_09 |