2-isobutyl-6-(2,4-difluorophenyl)-4-phthalimidomethyl-2H-pyridazin-3-one → 4-hydroxymethyl-2-isobutyl-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one

HRID 7994

반응식

HRID 7994 반응식
FC1C=C(F)C=CC=1C1C=C(CN2C(=O)C3=CC=CC=C3C2=O)C(=O)N(CC(C)C)N=1.[C:32]([C:35]1[C:36](=[O:53])[N:37]([CH2:49][CH:50]([CH3:52])[CH3:51])[N:38]=[C:39]([C:41]2[CH:46]=[CH:45][C:44]([S:47][CH3:48])=[CH:43][CH:42]=2)[CH:40]=1)(O)=[O:33]>>[OH:33][CH2:32][C:35]1[C:36](=[O:53])[N:37]([CH2:49][CH:50]([CH3:51])[CH3:52])[N:38]=[C:39]([C:41]2[CH:46]=[CH:45][C:44]([S:47][CH3:48])=[CH:43][CH:42]=2)[CH:40]=1

참가 물질

3

반응물 2

HCID 219915872-isobutyl-6-(2,4-difluorophenyl)-4-phthalimidomethyl-2H-pyridazin-3-oneHCID 219916394-carboxy-2-isobutyl-6-[4-(methylthio)phenyl)-2H-pyridazin-3-one

생성물 1

HCID 219916504-hydroxymethyl-2-isobutyl-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one수율 35.3%

실험 절차

Following the procedure of Example 1 (8), 4-carboxy-2-isobutyl-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one was reacted to yield the title compound as a yellow oil (yield: 35.3%).

후처리

  1. customwas reacted

출처 및 근거

ORD 기록
ord-4890823ff7fb4745a8939acecea10f65
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087606B2

연결된 노트

불러오는 중…