Propargylamine → 2-isobutyl-6-[4-(methylthio)phenyl]-4-propargylaminomethyl-2H-pyridazin-3-one

HRID 7996

반응식

HRID 7996 반응식
[CH2:1]([N:5]1[C:10](=[O:11])[C:9]([CH2:12]OS(C)(=O)=O)=[CH:8][C:7]([C:18]2[CH:23]=[CH:22][C:21]([S:24][CH3:25])=[CH:20][CH:19]=2)=[N:6]1)[CH:2]([CH3:4])[CH3:3].[CH2:26]([NH2:29])[C:27]#[CH:28]>>[CH2:1]([N:5]1[C:10](=[O:11])[C:9]([CH2:12][NH:29][CH2:26][C:27]#[CH:28])=[CH:8][C:7]([C:18]2[CH:23]=[CH:22][C:21]([S:24][CH3:25])=[CH:20][CH:19]=2)=[N:6]1)[CH:2]([CH3:4])[CH3:3]

참가 물질

3

반응물 2

HCID 239041PropargylamineHCID 219914882-isobutyl-4-methanesulfonyloxymethyl-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one

생성물 1

HCID 99241192-isobutyl-6-[4-(methylthio)phenyl]-4-propargylaminomethyl-2H-pyridazin-3-one수율 52.2%

실험 절차

Following the procedure of Example 1(10), 2-isobutyl-4-methanesulfonyloxymethyl-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one and propargylamine were reacted to yield the title compound as a yellow oil (yield: 52.2%).

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-a9661dee056c4c05b72bf31d6715bdc3
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087606B2

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