Trifluoromethanesulfonic anhydride → HCID 59611359, 화합물

HRID 79997노트

반응식

HRID 79997 반응식
[O:1]([S:9]([C:12]([F:15])([F:14])[F:13])(=[O:11])=[O:10])S(C(F)(F)F)(=O)=O.[Br:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[S:27][C:26]3[CH:28]=[C:29](O)[CH:30]=[CH:31][C:25]=3[CH:24]=2)=[CH:19][CH:18]=1>N1C=CC=CC=1>[Br:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[S:27][C:26]3[CH:28]=[C:29]([O:1][S:9]([C:12]([F:13])([F:14])[F:15])(=[O:10])=[O:11])[CH:30]=[CH:31][C:25]=3[CH:24]=2)=[CH:19][CH:18]=1

참가 물질

4

반응물 2

HCID 67749Trifluoromethanesulfonic anhydrideHCID 59611582HCID 59611582, 화합물

생성물 1

HCID 59611359HCID 59611359, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Tf2O was added slowly to a mixture of 2-(4-bromo-phenyl)-benzo[b]thiophen-6-ol (200 mg, 0.66 mol) in pyridine (3 mL) at 0° C. with stirring. The mixture was stirred at ambient temperature for 16 hours before quenched with NaHCO3 solution. The mixture was extracted with ethyl acetate (50 mL). The organic layer was washed with water and brine, dried over Na2SO4, filtered and concentrated in vacuo. The obtained residue was used for next step reaction without further purification.

후처리

  1. stirringThe mixture was stirred at ambient temperature for 16 hours
  2. custombefore quenched with NaHCO3 solution
  3. extractionThe mixture was extracted with ethyl acetate (50 mL)
  4. washThe organic layer was washed with water and brine
  5. dry with materialdried over Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo
  8. customThe obtained residue was used for next step reaction without further purification

출처 및 근거

ORD 기록
ord-025e7e38b9424159a35bf86649491031
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841278B2

반응 노트

불러오는 중…