8-Amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one → 5-Bromo-2-[5-chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide

반응식

[Br:14][c:15]1[cH:16][c:17]([F:34])[c:18]([NH:25][c:26]2[n:27][c:28]([Cl:33])[n:29][cH:30][c:31]2[Cl:32])[c:19]([C:20](=[O:21])[NH:22][CH3:23])[cH:24]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:13]1)[NH:7][C:8](=[O:12])[CH2:9][CH2:10][CH2:11]2>>[NH:1]([c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:13]1)[NH:7][C:8](=[O:12])[CH2:9][CH2:10][CH2:11]2)[c:28]1[n:27][c:26]([NH:25][c:18]2[c:17]([F:34])[cH:16][c:15]([Br:14])[cH:24][c:19]2[C:20](=[O:21])[NH:22][CH3:23])[c:31]([Cl:32])[cH:30][n:29]1

참가 물질

반응물 2

HCID 46151688-Amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one

HCID 866340355-bromo-2-(2,5-dichloro-pyrimidin-4-ylamino)-3-fluoro-N-methyl-benzamide

생성물 1

HCID 668301975-Bromo-2-[5-chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide

출처 및 근거

ORD 기록: ord-8df2df19d2b74d1c86622cb9c73bf6c7
출처 데이터셋: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

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