Potassium Carbonate → HCID 49872052, 화합물

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	1,2-Diaminocyclohexane, trans-	HCID 43806	—
반응물	2-Bromo-5-chlorothiophene	HCID 76133	—
반응물	1-(4-Methylpyridin-3-yl)imidazolidin-2-one	HCID 59636170	—
촉매	Copper iodide	HCID 83717	—
용매	1,4-Dioxane	HCID 31275	—
생성물	HCID 49872052	HCID 49872052	48.4%

반응 단계

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 300 mg, 1.6949 mmol) was reacted with 2-bromo-5-chloro-thiophene (0.185 mL, 1.6949 mmol), 1,4-dioxane (10 mL), copper iodide (32 mg, 0.169 mmol), trans-1,2-diamino cyclohexane (58 mg, 0.5084 mmol) and potassium carbonate (467 mg, 3.3898 mmol) to afford the crude product. Purification by column chromatography on silica gel (1% MeOH in DCM) afforded 240 mg of the product (48.4% yield).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	USRE045173E1
출처 데이터셋	uspto-grants-2014_09
ORD ID	ord-309efc0e89fa49868a29a272b273f658
출처 메모	uspto-grants-2014_09